| 名稱 | Recombinant Human BDNF |
| 型號 | |
| 更新時間 | 2023-09-24 |
| 特點 | 腦源性神經營養因子是神經生長因子家族的成員。和這個家庭的其他成員一樣,BDNF支持神經元增殖和生存。腦源性神經營養因子可以綁定一個細胞表面受體稱為LNGFR低親和力,也將其他neurotrophins如神經生長因子、NT-3 NT-4。} |
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- 詳細內容
一.產品名稱：Recombinant Human BDNF
二.貨號Catalog Number:AF-450-02
三.同義Synonyms:Brain Derived Neurotrophic Factor, Abrineurin
四.描述Description:
BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical. Manufactured using all non-animal reagents.
五.AA序列AA Sequence:
MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR
六.來源Source:E.coli
七.純度Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.
八.生物活性Biological Activity:
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
九.交叉反應性Cross Reactivity:
Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat, Human
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電話/傳真：13366128764
手機：15311648455
地址：北京市海淀區廂黃旗2號樓1層4-179室